Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection
- 作者：Christofer V. Samuelsson ; Stefan Lienenklaus ; Peter P. Mü ; ller ; Rainer Zawatzky ; Hansjö ; rg Hauser and Siegfried Weiss
- 关键词：Type I interferon ; Mouse fibroblast ; Immortalization ; Interferon regulatory factor ; Virus induction
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2005
- 期刊代码：159_0006291x
- 类别：bio
- 出版时间：2005
- 卷：335
- 期：2
- 页码：584-589
- 文件大小：842 K
摘要
Type I interferons (IFNs) have been shown to be involved in many immune defence and inflammatory responses. We here show that IFN-β plays an absolute essential role in the efficient induction of all type I IFNs after infection of primary embryonic as well as primary adult fibroblasts with Sendai virus. In contrast, after immortalization of such fibroblasts with SV40 large T antigen, IFN-α4 can be induced independently of IFN-β. However, efficient secretion of type I IFNs even in immortalized fibroblasts is only found when the complete signalling loop is induced by IFN-β.