A simple Tracerlab module modification for automated on-column [¹¹C]methylation and [¹¹C]carboxylation

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• 作者：Filippo Lodi ; Silvia Trespidi ; Donato Di Pierro ; Mario Marengo ; Mohsen Farsad ; Stefano Fanti ; Roberto Franchi ; Stefano Boschi
• 关键词：On-column [¹¹C]methylation ; [¹¹C]carboxylation ; [¹¹C] PET radiopharmaceuticals
• 刊名：Applied Radiation and Isotopes
• 出版年：2007
• 期刊代码：6_09698043
• 类别：ce
• 出版时间：June 2007
• 卷：65
• 期：6
• 页码：691-695
• 文件大小：502 K

摘要

A modification of commercial [¹¹C]methylation module which can be implemented for both on-column [¹¹C]methylation and [¹¹C]carboxylation in the same automated system is described. This module configuration was applied to the solid-phase synthesis of N-[¹¹C]methyl-choline ([¹¹C]choline) and L-(S-methyl-[¹¹C])methionine ([¹¹C]methionine), using [¹¹C]CH₃I as methylating agent, as well as to the synthesis of [¹¹C]acetate by [¹¹C]carboxylation with [¹¹C]CO₂ of methylmagnesium chloride with high and reproducible radiochemical yields in short reaction time, demonstrating to be a fast and reliable tool for the production of these [¹¹C]radiopharmaceuticals for clinical use.