Type 1 Interferons Cool the Inflamed Brain

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• 作者：Robert C. Axtell ; Lawrence Steinman
• 关键词：Aluminum trichloride ; Dithiocarbamate ; Ionic liquid ; Desulfurization ; Piperidinium
• 刊名：Immunity
• 出版年：2008
• 期刊代码：40_10747613
• 类别：imm
• 出版时间：16 May 2008
• 卷：28
• 期：5
• 页码：600-602
• 文件大小：239 K

摘要

Increasing efforts are done to characterize IFN expression and response in the CNS: to identify type I IFN producing cells, to decipher pathways leading to type I IFN expression in those cells, and to identify responding cells.

However, reversible and irreversible damages consecutive to chronic exposure of the CNS to type I IFNs underline the importance of a tightly regulated type I IFN homeostasis in this organ.