Steroidal saponins from Fritillaria pallidiflora Schrenk

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• 作者：Shuo Shen^a ; Guoyu Li^b ; Jian Huang^a ; Chaojun Chen^c ; Bu Ren^c ; Ga Lu^c ; Yong Tan^b ; Jiaxu Zhang^a ; Xian Li^a ; Jinhui Wang^a ; ^b ; ^c ; ^d ; ^{wjh.1972@yahoo.com.cn}
• 关键词：Fritillaria pallidiflora Schrenk ; Steroidal saponins ; NMR ; Cytotoxic activity
• 刊名：Fitoterapia
• 出版年：2012
• 期刊代码：35_0367326x
• 类别：ch
• 出版时间：June, 2012
• 卷：83
• 期：4
• 页码：785-794
• 文件大小：499 K

摘要

Five new steroidal saponins, Pallidifloside D (1), Pallidifloside E (2), Pallidifloside G (5), Pallidifloside H (6) and Pallidifloside I (7), together with seven other steroidal saponins (3, 4, 8-12) were isolated from the dry bulbs of Fritillaria pallidiflora Schrenk. Their structures were established by spectroscopic techniques (IR, MS, 1D and 2D NMR) and chemical means. The isolated steroidal saponins were evaluated for cyotoxic activity against human C6 brain gliomas and Hela cervix cancer cell lines using MTT assays. Compounds 1, 10, 11, 12 showed cytotoxicity against C6 and Hela cell lines with IC₅₀ values in the range of 5.1-75.8 渭M.