Desmettianosides A and B, bisdesmosidic furostanol saponins with molluscicidal activity from Yucca desmettiana

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• 作者：Yasser Diab^a ; ^b ; Efstathia Ioannou^a ; Ahmed Emam^b ; Constantinos Vagias^a ; ¹ ; Vassilios Roussis^a ; ^{roussis@pharm.uoa.gr}
• 关键词：Yucca desmettiana ; Desmettianosides A and B ; Furostanol saponins ; Structure elucidation ; Molluscicidal activity ; Biomphalaria alexandrina
• 刊名：Steroids
• 出版年：2012
• 期刊代码：142_0039128x
• 类别：bio
• 出版时间：May, 2012
• 卷：77
• 期：6
• 页码：686-690
• 文件大小：240 K

摘要

Bioactivity-guided separation of the aqueous methanolic extract of Yucca desmettiana leaves, which in a preliminary screening exhibited significant molluscicidal activity, led to the isolation and structure elucidation of two new steroidal saponins (1 and 2). The structures of desmettianosides A and B, identified as bisdesmosidic furostanol glycosides with six and five sugar units, respectively, were established by detailed spectroscopic analyses of their NMR and MS data. Compounds 1 and 2 exhibited high molluscicidal activity against Biomphalaria alexandrina snails with LC₁₀₀ values of 6 and 11 mg/L, respectively.