Highly oxygenated stigmastane-type steroids from the aerial parts of Vernonia anthelmintica Willd

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• 作者：Lei Hua^a ; Wei-Yan Qi^a ; Syed Hamid Hussain^b ; Kun Gao^a ; ^{npchem@lzu.edu.cn} ; Mohammad Arfan^b ; ^{m_arfan@upesh.edu.pk}
• 关键词：Vernonia anthelmintica Willd ; Vernoanthelcin A&ndash ; I ; Vernoantheloside A and B ; CD exciton chirality ; Estrogen biosynthesis ; KGN cells
• 刊名：Steroids
• 出版年：2012
• 期刊代码：142_0039128x
• 类别：bio
• 出版时间：June, 2012
• 卷：77
• 期：7
• 页码：811-818
• 文件大小：766 K

摘要

Nine new highly oxygenated stigmastane-type steroids, vernoanthelcin A-I (1-9), and two new stigmastane-type steroidal glycosides, vernoantheloside A and B (10 and 11) were isolated from the aerial parts of Vernonia anthelmintica Willd. The structures of compounds 1-11 were determined on the basis of IR, MS, 1D-NMR, and 2D-NMR, and their absolute configurations were deduced using single-crystal X-ray diffraction and the CD exciton chirality method. Compounds 1, 5, 7, 9 and 10 were tested for their effects on estrogen biosynthesis in human ovarian granulosa-like cells (KGN cells).