Re: Magnesium sulfate in the management of patients with aneurysmal subarachnoid hemorrhage: a randomized, placebo-controlled, dose-adapted trial (Muroi et al. Surg Neurol 2008;69:33-39)
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yle='font-weight: bold'>Results: Women outnumbered men by nearly 2:1. The population-adjusted female-to-male ratio increased with age (1.2:1 in the sixth decade, 2.1:1 in the seventh, and 2.9:1 in the later decades combined). The women in the study group were significantly older than the men. The level of consciousness and clot thickness on CT at admission were not significant different when comparing the genders. The location of the ruptured aneurysm varied between women and men. Women were found to have internal carotid aneurysms (32.5%of females vs. 18.9%of males, P < 0.0001) and multiple aneurysms (20.0%of females vs. 13.0%of males, P = 0.0017) more frequently than men. However men were found to have anterior communicating artery aneurysms (40.4%of males vs. 25.2%of females, P < 0.0001) more frequently than women. The incidence of preexisting arterial hypertension also varied by gender (49.7%in women vs. 39.0%in men, P = 0.0002). Women were more commonly found to have preexisting arterial hypertension than those in the National Epidemiological Survey. No gender-related differences were found in the overall incidence of vasospasm or the rebleeding rate. Assessment, using the Glasgow Outcome Scale did not reveal any significant difference in overall outcome between men and women.

yle='font-weight: bold'>Conclusion: These observations suggest that women (especially in the older age group) may have a risk factor for the formation and rupture of intracranial aneurysms. However, they do not have a worse prognosis than men following aneurysm rupture.


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Re: Magnesium sulfate in the management of patients with aneurysmal subarachnoid hemorrhage: a randomized, placebo-controlled, dose-adapted trial (Muroi et al. Surg Neurol 2008;69:33-39)

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