Beneficial effects of increasing monounsaturated fat intake in adolescents with type 1 diabetes

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• 作者：Donaghue ; K.C. ; Pena ; M.M. ; Chan ; A.K.F. ; Blades ; B.L. ; King ; J. ; Storlien ; L.H. ; Silink ; M.
• 关键词：Adolescents ; Monounsaturated fats ; n-9 Fatty acids ; Insulin-dependent diabetes mellitus
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2000
• 期刊代码：78_01688227
• 类别：med
• 出版时间：June, 2000
• 卷：48
• 期：3
• 页码：193-199
• 文件大小：96.4 K

摘要

This study aimed to increase the monounsaturated fat content in the diet of outpatient adolescents with type 1 diabetes and to examine the metabolic effects after 12 weeks. Twenty-three adolescents were randomly allocated to either a high monounsaturated fat diet or a control diet. Their mean age was 16.9 (S.D. 2.1) years and median HbAb>1cb> was 9.1%[IQR 7.9–10.4%]. Dietary targets were not reached judged by their 4-day food diaries. However, the whole study group had a significant increase in monounsaturated fat as indexed by red cell phospholipid fatty acids (RCFAs), with an increase of n-9 RCFAs from 14.9%[IQR: 14.5–21.7%] to 21.7%[IQR: 18.8–25.6%] (P=0.002). Changes in n-9 RCFAs were inversely related to changes in HbAb>1cb> (R²=0.26, P=0.02), such that a 10%increase in n-9 RCFAs corresponded to a 0.64%improvement (decrease) in HbAb>1cb>. Changes in n-9 RCFAs were also inversely related to changes in plasma total cholesterol (R²=0.38, P=0.002) and plasma LDL cholesterol (R²=0.21, P=0.03). These changes were not associated with changes in insulin dose, body weight or physical activity. Overall, the results demonstrate that a modest increase in the monounsaturated fat content of an adolescent diet has the potential to improve glycaemic control and lipid profile.