Differences in excitability between median and superficial radial sensory axons

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• 作者：Yumi Fujimaki^a ; ^b ; Kazuaki Kanai^a ; Sonoko Misawa^a ; Kazumoto Shibuya^a ; Sagiri Isose^a ; Saiko Nasu^a ; Yukari Sekiguchi^a ; Shigeki Ohmori^a ; Yu-ichi Noto^a ; Yumiko Kugio^b ; Toshio Shimizu^b ; Shiro Matsubara^b ; Cindy S.Y. Lin^c ; Satoshi Kuwabara^a ; ^{kuwabara-s@faculty.chiba-u.jp}
• 关键词：Axonal excitability ; Excitability testing ; Threshold tracking ; Sensory axon
• 刊名：Clinical Neurophysiology
• 出版年：2012
• 期刊代码：61_13882457
• 类别：med
• 出版时间：July, 2012
• 卷：123
• 期：7
• 页码：1440-1445
• 文件大小：393 K

摘要

Objective

The aim of this study was to investigate differences in excitability properties of human median and superficial radial sensory axons (e.g., axons innervating the glabrous and hairy skin in the hand). Previous studies have shown that excitability properties differ between motor and sensory axons, and even among sensory axons between median and sural sensory axons.

Methods

In 21 healthy subjects, threshold tracking was used to examine excitability indices such as strength-duration time constant, threshold electrotonus, supernormality, and threshold change at the 0.2 ms inter-stimulus interval in latent addition. In addition, threshold changes induced by ischemia for 10 min were compared between median and superficial radial sensory axons.

Results

Compared with radial sensory axons, median axons showed shorter strength-duration time constant, greater threshold changes in threshold electrotonus (fanning-out), greater supernormality, and smaller threshold changes in latent addition. Threshold changes in both during and after ischemia were greater for median axons.

Conclusions

These findings suggest that membrane potential in human median sensory axons is more negative than in superficial radial axons, possibly due to greater activity of electrogenic Na⁺/K⁺ pump. These results may reflect adaptation to impulses load carried by median axons that would be far greater with a higher frequency.

Significance

Biophysical properties are not identical in different human sensory axons, and therefore their responses to disease may differ.