Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp.

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• 作者：Shinji Kishimoto ; Yuta Tsunematsu ; Shinichi Nishimura ; Yutaka Hayashi ; Akira Hattori ; Hideaki Kakeya ; ^{scseigyo-hisyo@pharm.kyoto-u.ac.jp}
• 关键词：Cyclic lipodepsipeptide ; Streptomyces ; Methyl-branched fatty acid ; Antimicrobial
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：8 July, 2012
• 卷：68
• 期：27-28
• 页码：5572-5578
• 文件大小：521 K

摘要

Tumescenamide C, a new cyclic lipodepsipeptide, was isolated from a culture broth of an actinomycete Streptomyces sp. KUSC_F05. Tumescenamide C was a congener of tumescenamides A and B, representing a sixteen-membered ring system, consisting of two proteinogenic and three non-proteinogenic amino acids, to which a methyl-branched fatty acid was attached. The planar structure was determined by spectroscopic analysis, while its absolute stereochemistry was determined by chemical degradation and asymmetric synthesis. Tumescenamide C exhibited antimicrobial activity with high selectivity against Streptomyces species.