Katorazone, a new yellow pigment with a 2-azaquinone-phenylhydrazone structure produced by Streptomyces sp. IFM 11299

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• 作者：Mohamed S. Abdelfattah^a ; ^b ; Kazufumi Toume^a ; Midori A. Arai^a ; Hyuma Masu^c ; Masami Ishibashi^a ; ^{mish@chiba-u.jp}
• 关键词：Azaquinone ; Phenylhydrazone ; Streptomyces
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：27 June, 2012
• 卷：53
• 期：26
• 页码：3346-3348
• 文件大小：392 K

摘要

An unusual alkaloid with a 2-azaquinone-phenylhydrazone structure, katorazone (1), and other metabolites were isolated from the ethyl acetate extract of Streptomyces sp. IFM 11299. The chemical structure of katorazone (1) was elucidated by 1D and 2D NMR analyses together with HR-ESI mass spectrometry. Katorazone (1) showed a synergistic effect in combination with TRAIL and decreased the viability of human gastric adenocarcinoma (AGS) cells.