• 作者：Marí ; a Badí ; a Martí ; nez^a ; Maria Asunció ; n Garcí ; a-Gonzá ; lez^b ; ^c ; ^{asgarcia@unizar.es}
• 关键词：Cá ; ncer gá ; strico ; Helicobacter pylori ; Polimorfismos gené ; ticos
• 刊名：Medicina Cl铆nica
• 出版年：2011
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：12 November 2011
• 卷：137
• 期：12
• 页码：555-560
• 文件大小：302 K

Gastric cancer is a complex pathology which represents a worldwide health burden due to its high prevalence and poor prognosis. Therefore, prevention and early detection are considered the best options for controlling the disease. Current research is based on the study of genetic variants that confer a higher risk and their interactions with environmental exposure. A deeper knowledge of factors involved on gastric cancer development may allow identification of those individuals at elevated risk and will provide useful predictive information for subgroups of patients who need surveillance or early treatment strategies. In the present paper we review in a comprehensive manner, the most recent published studies on the contribution of gene polymorphisms and Helicobacter pylori infection to gastric cancer risk.