Preliminary findings of the effects of autonomic dysfunction on functional outcome after acute ischemic stroke

详细信息	查看全文 | 推荐本文 |

• 作者：Li Xiong ; Howan Leung ; Xiang Yan Chen ; Jing Hao Han ; Thomas Leung ; Yannie Soo ; Eddie Wong ; Anne Chan ; Alexander Lau ; Ka Sing Wong ; ^{ks-wong@cuhk.edu.hk}
• 关键词：Ischemic ; Stroke ; Autonomic dysfunction ; Outcome
• 刊名：Clinical Neurology and Neurosurgery
• 出版年：2012
• 期刊代码：60_03038467
• 类别：med
• 出版时间：May, 2012
• 卷：114
• 期：4
• 页码：316-320
• 文件大小：199 K

摘要

Background and purpose

Impaired autonomic function is common in the acute poststroke phase but little is known about its effects on functional outcome after acute ischemic stroke. This study sought to investigate the impact of autonomic dysfunction by Ewing's classification on functional outcome 2 months after acute ischemic stroke.

Methods

34 consecutive acute ischemic stroke patients within 7 days after onset were enrolled. On admission, autonomic function was assessed by Ewing's battery tests. Stroke severity was assessed by the National Institutes of Health Stroke Scale (NIHSS), autonomy in activities of daily living by the Barthel Index (BI), and global disability by the modified Rankin Scale (mRS). BI and mRS were also evaluated 2 months after ischemic stroke onset.

Results

On admission, eight patients were diagnosed as minor autonomic dysfunction and 26 patients as relatively severe autonomic dysfunction. The prevalence of relatively severe autonomic dysfunction in ischemic stroke patients was 76.5%. There were no significant differences in baseline characteristics between the minor and severe autonomic dysfunction groups. 2 months after stroke onset, the mean BI score of patients with minor autonomic dysfunction and severe autonomic dysfunction increased from 76.3 卤 15.3 on admission to 95.0 卤 7.1, 66.5 卤 15.2 on admission to 74.8 卤 15.9 respectively. The mean BI score after 2-month stroke onset and the change in BI from admission to 2-month outcome (delta BI) in patients with severe autonomic dysfunction were lower than those in patients with minor autonomic dysfunction (all P < 0.05).

Conclusions

Autonomic dysfunction occurs in acute stroke patients. Relatively severe autonomic dysfunction is related to an unfavorable functional outcome in patients with acute ischemic stroke.