Assessing the folding propensity of aliphatic units within helical aromatic oligoamide foldamers

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• 作者：Nicolas Delsuc^a ; Legiso Poniman^a ; Jean-Michel Lé ; ger^b ; Ivan Huc^a ; ^{i.huc@iecb.u-bordeaux.fr}
• 关键词：Foldamers ; Helical structures ; Structure elucidation ; Supramolecular chemistry ; X-raydiffraction
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：10 June, 2012
• 卷：68
• 期：23
• 页码：4464-4469
• 文件大小：671 K

摘要

Great attention is devoted to hybrid foldamers composed of more than one type of monomers. The folding of such hybrids requires units that may possess very different structures to be compatible. A method to assess this compatibility consists in studying the behavior of a monomer of one type within a sequence of another type of monomer. We have prepared and investigated the structure of flexible aliphatic monomers in the context of the rigid helices of quinoline-carboxamides. NMR and X-ray crystallography show that the rigid helical backbones may impart defined conformation into otherwise flexible units and that compatible folding modes exist between very different monomers.