Efficient fluoride-mediated synthesis of 5-alkyl amino- and ether-substituted pyrazoles

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• 作者：Andrei Shavnya ; Subas M. Sakya ; Martha L. Minich ; Bryson Rast ; Kristin Lundy DeMello and Burton H. Jaynes
• 关键词：Pyrazoles ; COX-2 inhibitors ; Fluoride mediated
• 刊名：Tetrahedron Letters
• 出版年：2005
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：2005
• 卷：46
• 期：40
• 页码：6887-6891
• 文件大小：129 K

摘要

Fluoride-mediated nucleophilic substitution reactions of 1-(4-methylsulfonyl (or sulfonamido)-2-pyridyl)-5-chloro-4-cyano pyrazoles with various amines and alcohols occur under mild conditions to provide the 5-alkyl amino and ether pyrazoles in moderate to high yields.