Thirty-four non-diabetic men with MetS and another 24 age-matched men without MetS were enrolled. In addition to fasting blood samples, the area of adipose tissue at the waist was assessed by magnetic resonance imaging (MRI).
There was no significant difference in serum BDNF concentrations between men with or without MetS (40.9 卤 8.0 vs. 43.2 卤 6.1 ng/ml, P = 0.235). However, the serum concentration of soluble vascular cell adhesion molecule-1 (VCAM-1) was higher in the subjects with a lower BDNF level (737 卤 230 vs. 628 卤 115 ng/ml, P = 0.025). An inverse correlation between VCAM-1 and BDNF was observed (r = 鈭?#xA0;0.391, P = 0.002). After adjusting for visceral adipose tissue, VCAM-1 was found to be independently associated with BDNF [95%confidence interval (鈭?#xA0;0.025, 鈭?#xA0;0.005), P = 0.004].
These data show no difference in serum BDNF levels between the men with MetS and controls. However, serum BDNF was inversely correlated with serum VCAM-1 in men without diabetes.