Traitement de la maladie thromboembolique veineuse chez le cancéreux
- 作者：D. Farge-Bancel ; L. Florea ; L. Bosquet ; P. Debourdeau
- 关键词：Cancer ; Venous thromboembolism ; Pulmonary embolism ; Anti-vitamin K ; Low-molecular weight-heparins ; Unfractionated heparin ; Doppler ultrasound
- 刊名：Pathologie Biologie
- 出版年：2008
- 期刊代码：216_03698114
- 类别：med
- 出版时间：June 2008
- 卷：56
- 期：4
- 页码：220-228
- 文件大小：179 K
摘要
Venous thromboembolism (VTE) disease, as defined by the occurence of deep venous thrombosis or pulmonary embolism, occurs among 4 to 20%of patients with cancer and is a leading cause of death among these patients. Use of classical anticoagulation to treat VTE in a cancer patient is associated with a higher risk of major bleeding and of VTE recurrence as compared to noncancer patients. Updated comprehensive and systematic review of current data from the medical literature allows to reconsider the classical approach used for anticoagulant treatment in cancer patients and to implement adapted recommendations. In 2008, the use of daily subcutaneous low-molecular-weight heparin (LMWH) for at least three to six months is recommended as first line therapy to treat VTE disease in cancer patients. If LMWH are contra-indicated (renal insuffisiency), other therapeutic appraoches are warranted, such as use of unfractionated heparin (UFH) with early introduction of anti-vitamin K for at least three months or venous cava filter in case of absolute contra-indications to anticoagulation. VTE prophylaxis in cancer patients relies on the same therapeutic approaches as currently used for noncancer patients at high risk of VTE. The definition of more specific prophylactic approaches for patients with cancer considered at higher risks of VTE, will be the subject of many clinical trials in the forthcoming years.