Following IV injection, maximum plasma heparin activities (Cmax) were 0.67 卤 0.14, 1.44 卤 0.22 and 2.87 卤 0.38 IU anti-FXa/mL, respectively. The calculated mean half-life (t陆) was between 39 and 57 min and was not significantly dose-dependent (P = 0.139). The volume of distribution (35-39 mL/kg) was almost equivalent to the plasma volume. After SC injection, Cmax values of 0.41 卤 0.10, 0.86 卤 0.17 or 1.91 卤 0.16 IU anti-FXa/mL, respectively, were calculated at 91-110 min post-injection. The t陆 values were between 106 and 122 min and were not significantly influenced by dose (P = 0.784). The bioavailability after SC injection was approximately 100%.
The high bioavailability of the SC administered LMWH dalteparin in cats was consistent with other species and indicated predictable blood levels. However, the comparatively short t陆 may indicate the necessity of multiple daily injections, which should be verified in clinical trials.