Study on the new bone cement based on calcium sulfate and Mg, CO3 doped hydroxyapatite
- 作者：Aneta Zima ; azima@agh.edu.pl ; Zofia Paszkiewicz ; Dominika Siek ; Joanna Czechowska ; Anna 艢ló ; sarczyk
- 关键词：B. Composites ; Bone cement ; Doped hydroxyapatite
- 刊名：Ceramics International
- 出版年：2012
- 期刊代码：13_02728842
- 类别：ms
- 出版时间：August, 2012
- 卷：38
- 期：6
- 页码：4935-4942
- 文件大小：1199 K
摘要
In order to improve some features of bone substitutes the new self-setting composite-type implant material based on Mg2+/CO32鈭?/sup> co-substituted hydroxyapatite (Mg-CHA) and calcium sulfate hemihydrate (CSH) was developed. Synthetic hydroxyapatites doped with small amounts of additives found in natural bone (e.g. Mg2+ and CO32鈭?/sup>) are regarded as promising components of calcium phosphate bone cements (CPCs). The CPCs, now available on the market, due to low resorption rate are too stable to permit material degradation and are slowly replaced by the newly formed bone. To improve cement resorption we used calcium sulfate which is a well-known biodegradable and biocompatible bone defect filler. Combining properties of Mg-CHA and CSH allowed developing a new, promising, easy shapeable implant material with high potential for bone regeneration.