An examination of environmental and genetic contributions to the determinants of suicidal behavior among male twins

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• 作者：April R. Smith^a ; Jessica D. Ribeiro^a ; Amy Mikolajewski^a ; Jeanette Taylor^a ; Thomas E. Joiner^a ; ^{asmith@psy.fsu.edu} ; William G. Iacono^b
• 关键词：Suicide ; Suicidal ideation ; Suicidal behavior ; Twin studies ; Heritability
• 刊名：Psychiatry Research
• 出版年：2012
• 期刊代码：225_01651781
• 类别：med
• 出版时间：15 May, 2012
• 卷：197
• 期：1-2
• 页码：60-65
• 文件大小：194 K

摘要

The purpose of the present study was to examine the relative association of genetic and environmental factors with individual differences in each of the proximal, jointly necessary, and sufficient causes for suicidal behavior, according to the Interpersonal-Psychological Theory of Suicide (IPTS; ). We examined data on derived scales measuring acquired capability, belongingness, and burdensomeness (the determinants of suicidal behavior, according to theory) from 348 adolescent male twins. Univariate biometrical models were used to estimate the magnitude of additive genetic (A), non-additive genetic (D), shared environmental (C), and non-shared environmental (E) effects associated with the variance in acquired capability, belongingness, and burdensomeness. The best fitting model for the acquired capability allowed for additive genetic and environmental effects, whereas the best fitting model for burdensomeness and belongingness allowed for shared and non-shared environmental effects. The present research extends prior work by specifying the environmental and genetic contributions to the components of the IPTS, and our findings suggest that belongingness and burdensomeness may be more appropriate targets for clinical intervention than acquired capability as these factors may be more malleable or amenable to change.