Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines

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• 作者：Paige E. Mahaney ; An T. Vu ; Casey C. McComas ; Puwen Zhang ; Lisa M. Nogle ; William L. Watts ; Ani Sarkahian ; Liza Leventhal ; Nicole R. Sullivan ; Albert J. Uveges ; et al.
• 关键词：Monoamine reuptake inhibitors ; Norepinephrine reuptake inhibitors ; Serotonin reuptake inhibitors ; Aryloxypropanamines
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2006
• 期刊代码：9_09680896
• 类别：ch
• 出版时间：15 December 2006
• 卷：14
• 期：24
• 页码：8455-8466
• 文件大小：245 K

摘要

Compounds with a combination of norepinephrine and serotonin reuptake inhibition have been approved in the US and Europe for a number of indications, including major depressive disorder and pain disorders such as diabetic neuropathy and fibromyalgia. Efforts to design selective norepinephrine reuptake inhibitors based on SAR from the aryloxypropanamine series of monoamine reuptake inhibitors have led to the identification of a potent new class of dual acting norepinephrine and serotonin reuptake inhibitors, namely the 3-(1H-indol-1-yl)-3-arylpropan-1-amines.