Simulation of stochastic micropopulation models--IV. Snappers: model implementation for genetic traits
- 作者：Goay ; Michael S.-C. ; Prasad ; Badri ; Gilbertson ; David ; Altmann ; Michael ; McGue ; Matthew K. ; et. al.
- 关键词：Genetic models ; Micropopulation model ; Stochastic simulation ; Genetic disease ; Monte Carlo techniques
- 刊名：Computers in Biology and Medicine
- 出版年：1995
- 期刊代码：70_00104825
- 类别：med
- 出版时间：November, 1995
- 卷：25
- 期：6
- 页码：519-531
- 文件大小：1.03 M
摘要
The current paper concerning stochastic micropopulation simulations describes SNAPPERS, which serves as a framework for simulation models of the genetic transmission of disease. The versions described are implemented using the simulation shell, SUMMERS, which includes the generic commonalities of several micropopulation models. Population members in SNAPPERS move through states related to the individual's status relative to the genotype (phenotype). Features of the model include one or two major loci, polygenic and common familial contribution to the phenotype, assortative mating, and flexibility in defining gene action. The user can select from multiple ascertainment strategies for analysis of simulated families.