Epol
act
aene, isol
ated f
rom cultu
red
Penicillium sp. BM 1689-P mycelium, induces neu
rite outg
rowth
and
arrests the cell cycle of the hum
an neu
robl
astom
a cell line, SH-SY5Y,
at the G1 ph
ase. We h
ave found th
at epol
act
aene
and its de
riv
atives induce
apoptosis in the hum
an leukemi
a B-cell line, BALL-1. In this study, we p
rep
ared fluo
rescent
and biotinyl
ated epol
act
aene de
riv
atives. We ch
aracte
rized the cellul
ar loc
ation
and the identific
ation of BALL-1 p
roteins th
at
re
acted with these compounds. The
results obt
ained f
rom the
re
action of epol
act
aene o
r its de
riv
ative with
N-
acetylcysteine methyl este
r indic
ate th
at these compounds induce the disulfide fo
rm
ation
and the
![]()
rc="http://www.sciencedi
rect.com/scidi
rimg/entities/204e.gif"
alt="g
reek sm
all lette
r alph
a" title="g
reek sm
all lette
r alph
a" bo
rde
r="0">-position of the epoxyl
act
am co
re is the
re
active site.