MS-920: DNA repair gene polymorphisms, diet and colorectal cancer risk in Taiwan

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• 作者：Yeh ; Chih-Ching ; Hsieh ; Ling-Ling ; Tang ; Reiping ; Chang-Chieh ; Chung Rong ; Sung ; Fung-Chang
• 关键词：Colorectal cancer ; XRCC1 ; XRCC3 ; XPD ; Polymorphisms ; Diet
• 刊名：Cancer Letters
• 出版年：2005
• 期刊代码：44_03043835
• 类别：med
• 出版时间：June 28, 2005
• 卷：224
• 期：2
• 页码：279-288
• 文件大小：130 K

摘要

This hospital-based case–control study examined whether polymorphic DNA repair genes: XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln, play a role in the susceptibility to colorectal cancer. We genotyped these polymorphisms for 727 newly diagnosed colorectal adenocarcinoma cases and 736 age and sex matched healthy controls in Taiwan. Although the colorectal cancer risk was not significantly associated with these genes, the risk was significantly elevated in younger subjects (≤60 years) with the XRCC1 399Arg/Arg genotype compared to those with XRCC1 399Gln allele (OR=1.46, 95%CI=1.06–2.99, P