Reprint of: Betaglycan: A multifunctional accessory
- 作者：Maree Bilandzic ; maree.bilandzic@princehenrys.org ; Kaye L. Stenvers
- 关键词：Betaglycan ; TGF尾 receptor III ; Inhibin
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2012
- 期刊代码：109_03037207
- 类别：bio
- 出版时间：15 August, 2012
- 卷：359
- 期：1-2
- 页码：13-22
- 文件大小：579 K
摘要
Betaglycan is a co-receptor for the TGF尾 superfamily, particularly important in establishing the potency of its ligands on their target cells. In recent years, new insights have been gained into the structure and function of betaglycan, expanding its role from that of a simple co-receptor to include additional ligand-dependent and ligand-independent roles. This review focuses on recent advances in the betaglycan field, with a particular emphasis on its newly discovered actions in mediating the trafficking of TGF尾 superfamily receptors and as a determinant of the functional output of TGF尾 superfamily signalling. In addition, this review encompasses a discussion of the emerging roles of the betaglycan/inhibin pathway in reproductive cancers and disease.