Signaling by estrogens and tamoxifen in the human endometrium
- 作者：Susanne C.J.P. Gielen ; Lindy A.M. Santegoets ; Payman Hanifi-Moghaddam ; Curt W. Burger ; Leen J. Blok
- 关键词：Estrogen ; Tamoxifen ; Endometrium ; Gene expression
- 刊名：The Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2008
- 期刊代码：172_09600760
- 类别：med
- 出版时间：April 2008
- 卷：109
- 期：3-5
- 页码：219-223
- 文件大小：246 K
摘要
Tamoxifen is used as adjuvant treatment for postmenopausal breast cancer patients. The mechanism of action of tamoxifen in breast cancer patients is that tamoxifen inhibits growth of cancer cells by competitive antagonism for estrogens at the estrogen receptor (ER). In the endometrium, tamoxifen has an effect that varies with the ambient concentration of estrogen: in premenopausal women (high estrogen levels), tamoxifen displays an estrogen-antagonistic effect, while in postmenopausal women (low estrogen levels), tamoxifen displays an estrogen-agonistic mode of action. Here, using microarray technology we have compared estrogen signaling with tamoxifen signaling in the human endometrium.