Hepatitis C virus Core Antigen as a predictor of non-response in genotype 1 chronic hepatitis C patients treated with peginterferon α-2b plus ribavirin
- 作者：Buti ; Maria ; Mendez ; Claudia ; Schaper ; Melanie ; Sauleda ; Silvia ; Valdes ; Auristela ; Rodriguez-Frias ; Francisco ; et. al.
- 关键词：Pegylated interferon ; Ribavirin ; HCV Core Ag ; Hepatitis C virus RNA ; Hepatitis C ; Therapy ; Sustained virologic response ; ALT ; alanine transferase ; HCV ; hepatitis C virus ; NS ; not significant ; PEG-IFN ; pegylated interferon α ; -2b ; Total ; HCV Core Ag ; to
- 刊名：Journal of Hepatology
- 出版年：2004
- 期刊代码：162_01688278
- 类别：med
- 出版时间：March, 2004
- 卷：40
- 期：3
- 页码：527-532
- 文件大小：332 K
摘要
Chronic hepatitis C patients infected by genotype 1 are the least responsive to combination therapy and therefore monitoring response is important in identifying non-responders quickly, permitting therapy discontinuation and avoiding side effects and costs. We examined the usefulness of measuring total HCV Core Ag in early treatment with peginterferon α-2b and ribavirin in genotype 1 patients in the prediction of response and compared the results with those from HCV RNA quantification.