Mice lacking Wnt2b are viable and display a postnatal olfactory bulb phenotype

详细信息	查看全文 | 推荐本文 |

• 作者：Tadasuke Tsukiyama^a ; ^b ; ^{tsukit@med.hokudai.ac.jp} ; Terry P. Yamaguchi^a
• 关键词：A&ndash ; P ; anterior&ndash ; posterior ; PS ; primitive streak ; OpV ; optic vesicle ; OtV ; otic vesicle ; OfB ; olfactory bulb ; Hp ; hippocampus ; SVZ ; subventricular zone
• 刊名：Neuroscience Letters
• 出版年：2012
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：14 March, 2012
• 卷：512
• 期：1
• 页码：48-52
• 文件大小：905 K

摘要

Wnts are secreted glycoproteins that play important roles in embryonic development. Wnt2b is transiently expressed in the primitive streak (PS) during gastrulation and in several organs during organogenesis. To determine the biological function of Wnt2b during mouse development, we established a conditional null allele of Wnt2b. Mice lacking Wnt2b were viable, fertile, and displayed a normal life span, however, the olfactory bulb in adult Wnt2b mutant mice was significantly reduced in length. Our results suggest that Wnt2b primarily plays a supportive role in gastrulation and organogenesis, functioning redundantly with canonical Wnts, such as Wnt2, in numerous tissues.