Attractive guidance: How the chemokine SDF1/CXCL12 guides different cells to different locations

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• 作者：Stephen W. Lewellis^a ; ^{stephen.lewellis@med.nyu.edu} ; Holger Knaut^a ; ^b ; ^{holger.knaut@med.nyu.edu}
• 关键词：PGC ; primordial germ cell ; MZ ; marginal zone ; IZ ; intermediate zone ; SVZ ; subventricular zone ; CR cells ; Cajal-Retzius cells
• 刊名：Seminars in Cell and Developmental Biology
• 出版年：2012
• 期刊代码：186_10849521
• 类别：bio
• 出版时间：May, 2012
• 卷：23
• 期：3
• 页码：333-340
• 文件大小：782 K

摘要

During the development and adult life of multicellular organisms cells move from one location to another as they assemble into organs, seal a wound or fight pathogens. For navigation, migrating cells follow cues that guide them to their final position. Frequently, a single cue simultaneously guides different cells to different positions. Recent studies of one such cue鈥攖he chemokine SDF1鈥攕uggest strategies for how the animal achieves this task without causing erroneous migration.