Methylphenidate sensitization is prevented by prefrontal cortex lesion

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• 作者：Min J. Lee ; Alan C. Swann ; Nachum Dafny
• 关键词：Behavioral sensitization ; Methylphenidate ; Prefrontal cortex ; Lesion ; Acute and chronic treatment ; Withdrawal
• 刊名：Brain Research Bulletin
• 出版年：2008
• 期刊代码：9_03619230
• 类别：neu
• 出版时间：15 May 2008
• 卷：76
• 期：1-2
• 页码：131-140
• 文件大小：888 K

摘要

Methylphenidate (MPD), also known as Ritalin, is a widely used treatment for Attention Deficit Hyperactivity Disorder. Repeated administration of MPD causes dose-dependent sensitization. MPD binds to dopamine (DA) transporters, and DA, therefore, remain in the synaptic cleft for longer time, resulting in an indirect DA agonist effect. MPD affects neurotransmission in brain regions including the prefrontal cortex (PFC). The mechanisms of sensitization to MPD are not clear.