Synthesis and anti-tubulin evaluation of chromone-based analogues of combretastatins

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• 作者：Jé ; rô ; me Quintin ; Catherine Roullier ; Sylviane Thoret and Guy Lewin
• 关键词：Flavones ; Citrus flavonoids ; Combretastatins ; Tubulin
• 刊名：Tetrahedron
• 出版年：2006
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：24 April 2006
• 卷：62
• 期：17
• 页码：4038-4051
• 文件大小：568 K

摘要

Twenty new hybrid compounds with both combretastatin and flavone moieties were synthesized. These derivatives are classified according to the position of the trimethoxyphenyl ring at C-2 or C-3 of the chromone and presence or absence of a carbonyl as a linker between C-3 and the aryl ring. Most of these compounds were prepared from hesperidin or naringin, two natural and abundant Citrus flavonoids. Seven of these combretastatin analogues revealed anti-tubulin activity but in a medium range.