Chemokine profile in the cerebrospinal fluid and serum of Vogt脙脙脙脙脙脙Koyanagi脙脙脙脙脙脙Harada disease

详细信息	查看全文 | 推荐本文 |

• 作者：Miyazawa ; Isabelle ; Abe ; Toshiaki ; Narikawa ; Koichi ; Feng ; Juan ; Misu ; Tatsuro ; Nakashima ; Ichiro ; et. al.
• 关键词：Vogt脙脙脙脙脙脙Koyanagi脙脙脙脙脙脙Harada disease ; Uveitis ; Chemokine
• 刊名：Journal of Neuroimmunology
• 出版年：2005
• 期刊代码：32_01655728
• 类别：neu
• 出版时间：January, 2005
• 卷：158
• 期：1-2
• 页码：240-244
• 文件大小：218 K

摘要

We analyzed the concentrations of four chemokines in the cerebrospinal fluid (CSF) and sera in Vogt–Koyanagi–Harada disease (VKH), an autoimmune uveomeningitis syndrome against melanocyte-associated proteins, with ELISA. CSF-CXCL10/IP-10 and CSF-CCL17/TARC were significantly elevated in VKH than in controls. In the majority of VKH cases and controls, CSF-CXCL10 was higher than serum-CXCL10, and CSF-CCL17 was lower than serum-CCL17. CCL11/Eotaxin was not different between groups. CSF-CCL2/MCP-1 was significantly lower in VKH than in control. The changes in VKH were essentially similar to those in multiple sclerosis, a known Th1-dominant condition.