Chemical synthesis of funicone analogs

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• 作者：Emiliano Manzo ; ^{emanzo@icb.cnr.it} ; ^{emanzo@icmib.na.cnr.it} ; Maria Letizia Ciavatta
• 关键词：Rapicone ; Deoxyfunicone ; Funicone analogs ; Chemical synthesis
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：3 June, 2012
• 卷：68
• 期：22
• 页码：4107-4111
• 文件大小：461 K

摘要

Deoxyfunicone, rapicone and their 5,6-epoxy-derivatives are 纬-pyrone compounds with cytostatic and antiproliferative properties. Here we describe a synthesis of these compounds by carbonylative Stille coupling between kojic acid derivatives and functionalized iodo aryl compounds. The main advantages of this patent pending synthetic strategy lie in the simplicity and clean conversion of products, and in the possibility to obtain a high number of analogs by minor changes of the synthetic synthons.