Enantioselective total synthesis of eudistomidins G, H, and I

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• 作者：Haruaki Ishiyama ; Kazuaki Yoshizawa ; Jun'ichi Kobayashi ; ^{jkobay@pharm.hokudai.ac.jp}
• 关键词：Total synthesis ; Eudistomidins G ; H ; and I ; Eudistoma glaucus ; Absolute configuration
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：5 August, 2012
• 卷：68
• 期：31
• 页码：6186-6192
• 文件大小：354 K

摘要

Asymmetric first total synthesis of eudistomidins G, H, and I, tetrahydro-尾-carboline alkaloids from the Okinawan marine tunicate Eudistoma glaucus, has been accomplished with the Bischler-Napieralski reaction and the Noyori catalytic asymmetric hydrogen-transfer reaction. The absolute configurations of eudistomidins G, H, and I were confirmed from comparison of the ¹H and ¹³C NMR, and CD spectral data of synthetic and natural eudistomidins G, H, and I, respectively.