Mg(ClO₄)₂-catalyzed intramolecular allylic amination: application to the total synthesis of demethoxyfumitremorgin C

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• 作者：Danfeng Jiang^a ; Zhengren Xu^a ; Yanxing Jia^a ; ^b ; ^{yxjia@bjmu.edu.cn}
• 关键词：Amination ; Total synthesis ; Natural product ; Nitrogen heterocycles ; Magnesium
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：3 June, 2012
• 卷：68
• 期：22
• 页码：4225-4232
• 文件大小：576 K

摘要

A Mg(ClO₄)₂-catalyzed intramolecular amination of allylic alcohols with carbamate or sulfonamide nucleophiles to form substituted piperidine and pyrrolidine derivatives has been developed. This method has been successfully applied to the total synthesis of demethoxyfumitremorgin C.