Enantiospecific first total synthesis of 7a(S)-p-hydroxyphenopyrrozin

详细信息	查看全文 | 推荐本文 |

• 作者：Yugandhar Kothapalli ; Ravi Kumar Puthukanoori ; ^{ravikumar@gvkbio.com} ; Srinivasa Rao Alapati
• 关键词：Phenopyrrozin ; 7a(S)-p-Hydroxyphenopyrrozin ; Base mediated oxygenation ; Enantiospecific ; Total synthesis
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：11 April, 2012
• 卷：53
• 期：15
• 页码：1891-1893
• 文件大小：427 K

摘要

An enantiospecific first total synthesis of metabolite 7a(S)-p-hydroxyphenopyrrozin 2, isolated from the cultured fungi Chromocleista sp. has been achieved starting from readily and abundantly available l-proline. The strategy of synthesis utilizes base mediated cyclization and base mediated oxygenation as the key steps.