Overexpression of COX-2 and LMP1 are correlated with lymph node in Tunisian NPC patients
- 作者：Ali Fendri ; Abdelmajid Khabir ; Boutheina Hadhri-Guiga ; Tahia Sellami-Boudawara ; Abdelmoonem Ghorbel ; Jamel Daoud ; Mounir Frikha ; Rachid Jlidi ; Ali Gargouri ; Raja Mokdad-Gargouri
- 关键词：Cyclooxygenase-2 ; Nasopharyngeal carcinoma ; Latent membrane protein 1 ; Overexpression
- 刊名：Oral Oncology
- 出版年：2008
- 期刊代码：213_13688375
- 类别：med
- 出版时间：July 2008
- 卷：44
- 期：7
- 页码：710-715
- 文件大小：385 K
摘要
Cyclooxygenase 2 (COX-2) an inducible form of COX is frequently up-regulated in many human tumours. The expression of COX-2 in nasopharyngeal carcinoma (NPC) and its relationship to clinicopathological features were studied in Tunisian patients. COX-2 mRNA was detected in 91%of tumour tissues. Immunohistochemical analysis showed that COX-2 protein was strongly detected in tumour cells and the staining was mainly cytoplasmic. In contrast, COX-2 mRNA and protein were very low or undetectable in normal nasopharyngeal mucosa. Our result showed a significant association of COX-2 overexpression with the lymph node involvement, however, no correlation was observed with age, tumour stage, histological type and distant metastasis. Moreover, we showed that all tumour specimens co-overexpressed COX-2 and the EBV oncoprotein LMP1 corroborating the fact that LPM1 is known to induce COX-2. Altogether, our data suggests that the COX-2 is overexpressed in NPC biopsies and that is linked to the lymph node involvement.