Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2
- 作者：Yoko Okitsu ; Shinichiro Takahashi ; Naoko Minegishi ; Junichi Kameoka ; Mitsuo Kaku ; Masayuki Yamamoto ; Takeshi Sasaki ; Hideo Harigae
- 关键词：GATA-2 ; Adipocyte differentiation ; Bone marrow
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2007
- 期刊代码：159_0006291x
- 类别：bio
- 出版时间：14 December 2007
- 卷：364
- 期：2
- 页码：383-387
- 文件大小：250 K
摘要
GATA-2 is a transcription factor expressed in stem and progenitor cells of various cell lineages. In this study, we examined the role of GATA-2 in the differentiation of adipocytes, which are the main components of the microenvironment for hematopoiesis. Suppression of GATA-2 in TBR343, a preadipocytic stromal cell line, resulted in the acceleration of adipocyte differentiation. Conversely, overexpression of GATA-2 induced the resistance of adipocyte differentiation. In addition, regulatory elements of the GATA-2 gene in TBR343 are the same as those in hematopoietic cells. These results suggest that GATA-2 maintains a hematopoietic microenvironment by regulating the differentiation of adipocytes.