Tricalysiosides H–O: Ent-kaurane glucosides from the leaves of Tricalysia dubia

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• 作者：Dong-Hui He ; Katsuyoshi Matsunami ; Hideaki Otsuka ; Takakazu Shinzato ; Mitsunori Aramoto ; Masahiko Bando and Yoshio Takeda
• 关键词：Tricalysia dubia ; Rubiaceae ; Ent-kaurane glucoside ; Tricalysiosides H– ; O ; X-ray analysis
• 刊名：Phytochemistry
• 出版年：2005
• 期刊代码：85_00319422
• 类别：ch
• 出版时间：December 2005
• 卷：66
• 期：24
• 页码：2857-2864
• 文件大小：227 K

摘要

Eight ent-kaurane glucosides, named tricalysiosides H–O (1–8), were isolated from Tricalysia dubia. Tricalysioside H (1) possessed a hydroxyl group at the 1-position, to which the glucose moiety was attached. The structure was first elucidated by means of spectroscopic data analysis and finally confirmed by X-ray crystallography. Since acid hydrolysis of 1 gave d-glucose, the aglycone was proved to have an enantio-kaurane type skeleton. The structures of tricalysiosides I–O (2–8) were mainly elucidated from analysis of spectroscopic evidence.