Factors predicting perforation during endoscopic submucosal dissection for gastric cancer

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• 作者：Takashi Ohta ; MD ; Ryu Ishihara ; MD ; Noriya Uedo ; MD ; Yoji Takeuchi ; MD ; Kengo Nagai ; MD ; Fumi Matsui ; MD ; Natsuko Kawada ; MD ; Takeshi Yamashina ; MD ; Hiromitsu Kanzaki ; MD ; Masao Hanafusa ; MD ; Sachiko Yamamoto ; MD ; Noboru Hanaoka ; MD ; Koji Higashino ; MD ; Hiroyasu Iishi ; MD
• 关键词：ESD ; endoscopic submucosal dissection
• 刊名：Gastrointestinal Endoscopy
• 出版年：2012
• 期刊代码：130_00165107
• 类别：med
• 出版时间：June, 2012
• 卷：75
• 期：6
• 页码：1159-1165
• 文件大小：228 K

摘要

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Background

Perforation is a common complication of endoscopic submucosal dissection (ESD), but little is known about the relevant risk factors.

Objective

To investigate the risk factors for perforation.

Design

Retrospective study.

Setting

A cancer referral center.

Patients

A total of 1795 early gastric tumors in 1500 patients treated by ESD from July 2002 to December 2010 were included in the analysis.

Main Outcome Measurements

The associations between the incidence of perforation and patient and lesion characteristics were investigated.

Results

Perforation during ESD occurred in 50 lesions (2.8%). Univariate analysis identified tumor location (upper, middle, or lower stomach), tumor diameter (鈮?0 or >20 mm), and treatment period (lesions treated in the first or second period) as predictors of perforation. Multivariate analysis identified tumor location (upper stomach), tumor diameter (>20 mm), and treatment period (first half) as independent risk factors for perforation. The odds ratios were 2.4 (95%CI, 1.3-4.7; P = .006) for lesions in the upper stomach and 1.9 (95%CI, 1.0-3.5; P = .04) for lesions larger than 20 mm. Perforation risks were 5.4%for lesions in the upper stomach and 4.4%for lesions larger than 20 mm. Three patients required emergency surgery, but the rest of the patients were successfully treated with endoscopic clipping. There was no perforation-related mortality.

Limitations

Single-center, retrospective study design.

Conclusions

Lesions in the upper stomach and lesions larger than 20 mm were independent risk factors for perforation during ESD. Patients should be made aware of the estimated high risks of these lesions before undergoing ESD.