Antibiotics and Topical Nasal Steroid for Treatment of Acute Maxillary Sinusitis: Williamson IG, Rumsby K, Benge S, et al. JAMA 2007;21:2487–96

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• 作者：Brad Talley
• 关键词：Air cargo ; Deregulation ; Global production networks ; Europe
• 刊名：Journal of Emergency Medicine
• 出版年：2008
• 期刊代码：156_07364679
• 类别：med
• 出版时间：May 2008
• 卷：34
• 期：4
• 页码：491-492
• 文件大小：55 K

摘要

Adult patients with suspected acute maxillary sinusitis were referred by general practitioners for radiographs of the maxillary sinus. Those with radiographic abnormalities (n=214) were randomly assigned treatment with amoxycillin (750 mg three times daily for 7 days; n=108) or placebo (n=106). Clinical course was assessed after 1 week and 2 weeks, and reported relapses and complications were recorded during the following year.

Findings

After 2 weeks, symptoms had improved substantially or disappeared in 83%of patients in the study group and 77%of patients taking placebo. Amoxycillin did not influence the clinical course of maxillary sinusitis nor the frequency of relapses during the 1-year follow-up. Radiographs had no prognostic value, nor were they an effect modifier. Side-effects were recorded in 28%of patients given amoxycillin and in 9%of those taking placebo (p<0·01). The occurrence of relapses was similar in both groups (21 vs 17%) during the follow-up year.

Interpretation

Antibiotic treatment did not improve the clinical course of acute maxillary sinusitis presenting to general practice. For these patients, an initial radiographic examination is not necessary and initial management can be limited to symptomatic treatment. Whether antibiotics are necessary in more severe cases warrants further study.div>div>
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Otolaryngology - Head and Neck Surgery, Volume 115, Issue 2, August 1996, Page P149
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Abstract

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Antibiotics and Topical Nasal Steroid for Treatment of Acute Maxillary Sinusitis Williamson IG, Rumsby K, Benge S, et al. JAMA 2007;21:2487–96