Phenytoin desensitization in a child with symptomatic localization-related epilepsy
- 作者：Seiko Itomi ; Akihisa Okumura ; Taketo Ikuta ; Tamiko Negoro ; Kazuyoshi Watanabe
- 关键词：Desensitization ; Phenytoin ; Hypersensitivity
- 刊名：Brain and Development
- 出版年：2007
- 期刊代码：40_03877604
- 类别：med
- 出版时间：March 2007
- 卷：29
- 期：2
- 页码：121-123
- 文件大小：79 K
摘要
We reported a child with refractory partial seizures successfully managed by clinical desensitization to phenytoin. The patient had ischemic brain lesions due to cardiopulmonary arrest at 39 weeks of corrected age. He had complex partial seizures refractory to several antiepileptic drugs since 4 years of age. At 8 years 1 month of age, phenytoin was first administered. Fever and maculopapular rashes appeared at 10 days after phenytoin initiation, and then the drug was discontinued. At 8 years 8 months of age, desensitization was attempted because of refractoriness of seizures to drugs other than phenytoin. Desensitization was started at 1 mg daily, and then the dose was doubled every week. His seizures were controlled by 150 mg/day of phenytoin in combination with primidone. No problems have been observed during desensitization.