Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder

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• 作者：Barr ; Cathy L. ; Xu ; Chun ; Kroft ; Jamie ; Feng ; Yu ; Wigg ; Karen ; Zai ; Gwyneth ; Tannock ; Rosemary ; et. al.
• 关键词：Genetics ; dopamine transporter ; attention-deficit/hyperactivity disorder ; transmission disequilibrium test ; haplotypes ; polymorphism
• 刊名：Biological Psychiatry
• 出版年：2001
• 期刊代码：34_00063223
• 类别：med
• 出版时间：February 15, 2001
• 卷：49
• 期：4
• 页码：333-339
• 文件大小：46.4 K

摘要

Background: Attention-deficit/hyperactivity disorder (ADHD) is often treated using methylphenidate, a psychostimulant that inhibits the dopamine transporter. This led E.H. Cook and colleagues to consider the dopamine transporter locus (DAT1) as a primary candidate gene for ADHD. That group reported a significant association between ADHD and the 480-base pair (bp) allele of the variable number of tandem repeats (VNTR) polymorphism located in the 3′ untranslated region of the DAT1 gene. This association was later replicated in additional studies.