Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: A longitudinal study

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• 作者：Jennifer Moodie^a ; Brian C. Healy^b ; Guy J. Buckle^b ; Susan A. Gauthier^c ; Bonnie I. Glanz^b ; Ashish Arora^b ; Antonia Ceccarelli^b ; Shahamat Tauhid^b ; Xue-Mei Han^b ; Arun Venkataraman^b ; Tanuja Chitnis^b ; Samia J. Khoury^b ; Charles R.G. Guttmann^d ; Howard L. Weiner^b ; Mohit Neema^b ; ¹ ; ^{mneema@bwh.harvard.edu} ; Rohit Bakshi^b ; ¹
• 关键词：MRI ; Multiple sclerosis ; Neurologic disability ; T1 hypointense lesions ; T2 hyperintense lesions ; Brain atrophy ; Measurement scales
• 刊名：Journal of the Neurological Sciences
• 出版年：2012
• 期刊代码：178_0022510x
• 类别：med
• 出版时间：15 April, 2012
• 卷：315
• 期：1-2
• 页码：49-54
• 文件大小：185 K

摘要

Background

We previously described a composite MRI scale combining T1-lesions, T2-lesions and whole brain atrophy in multiple sclerosis (MS): the magnetic resonance disease severity scale (MRDSS).

Objective

Test strength of the MRDSS vs. individual MRI measures for sensitivity to longitudinal change.

Methods

We studied 84 MS patients over a 3.2 卤 0.3 year follow-up. Baseline and follow-up T2-lesion volume (T2LV), T1-hypointense lesion volume (T1LV), and brain parenchymal fraction (BPF) were measured. MRDSS was the combination of standardized T2LV, T1/T2 ratio and BPF.

Results

Patients had higher MRDSS at follow-up vs. baseline (p < 0.001). BPF decreased (p < 0.001), T1/T2 increased (p < 0.001), and T2LV was unchanged (p > 0.5). Change in MRDSS was larger than the change in MRI subcomponents. While MRDSS showed significant change in relapsing-remitting (RR) (p < 0.001) and secondary progressive (SP) phenotypes (p < 0.05), BPF and T1/T2 ratio changed only in RRMS (p < 0.001). Longitudinal change in MRDSS was significantly different between RRMS and SPMS (p = 0.0027); however, change in the individual MRI components did not differ. Evaluation with respect to predicting on-study clinical worsening as measured by EDSS revealed a significant association only for T2LV (p = 0.038).

Conclusion

Results suggest improved sensitivity of MRDSS to longitudinal change vs. individual MRI measures. MRDSS has particularly high sensitivity in RRMS.