Comparison of serum and urinary C-terminal telopeptide of type I collagen in aging, menopause and osteoporosis
- 作者：Kawana ; K. ; Takahashi ; M. ; Hoshino ; H. ; Kushida ; K.
- 关键词：Bone marker ; Bone resorption ; Menopause ; Vertebral fracture ; Hip fracture
- 刊名：Clinica Chimica Acta
- 出版年：2002
- 期刊代码：54_00098981
- 类别：med
- 出版时间：February, 2002
- 卷：316
- 期：1-2
- 页码：109-115
- 文件大小：301 K
摘要
Background: Urinary C-terminal telopeptide of type I collagen (u-CTx) has been reported to be a sensitive biochemical marker of bone turnover. There have been two assays for urinary CTx, which are α-CTx and β-CTx. A newly developed immunoassay for serum CTx (s-CTx) is now available for assessment of bone resorption. We evaluated the effects of aging, menopause, and osteoporosis on the measurements of serum CTx and compared them to urinary CTx assays. Methods: In 79 premenopausal healthy women, 80 postmenopausal healthy women, 61 osteoporotic patients with vertebral fractures and 34 osteoporotic patients with hip fractures, s-CTx and urinary β-CTx (u-βCTx) were measured by ELISAs, and urinary α-CTx (u-αCTx) was measured by an RIA. Results: In all subjects, s-CTx significantly correlated with both u-αCTx (r