- 作者：Chelsea Pinnix ; M.D. ; Ph.D.&lowast ; ; George H. Perkins ; M.D. ; M.P.H.&lowast ; ; Eric A. Strom ; M.D.&lowast ; ; Welela Tereffe ; M.D. ; M.P.H.&lowast ; ; Wendy Woodward ; M.D. ; Ph.D.&lowast ; ; Julia L. Oh ; M.D.&lowast ; ; Lisa Arriaga ; R.N.&lowast ; ; Mark F. Munsell ; M.S.&dagger ; ; Patrick Kelly ; M.D. ; Ph.D.&lowast ; ; Karen E. Hoffman ; M.D. ; M.H.Sc. ; M.P.H.&lowast ; ; Benjamin D. Smith ; M.D.&lowast ; ; Thomas A. Buchholz ; M.D.&lowast ; ; T. Kuan Yu ; M.D. ; Ph.D.&Dagger ; ; tkyu@houstonprecisioncc.com
- 关键词：Radiation dermatitis ; Breast cancer ; Hyaluronic acid ; Petrolatum gel
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2012
- 期刊代码：136_03603016
- 类别：med
- 出版时间：15 July, 2012
- 卷：83
- 期：4
- 页码：1089-1094
- 文件大小：158 K
Purpose
To determine the efficacy of an emulsion containing hyaluronic acid to reduce the development of 鈮rade 2 radiation dermatitis after adjuvant breast radiation compared with best supportive care.Methods and Materials
Women with breast cancer who had undergone lumpectomy and were to receive whole-breast radiotherapy to 50 Gy with a 10- to 16-Gy surgical bed boost were enrolled in a prospective randomized trial to compare the effectiveness of a hyaluronic acid-based gel (RadiaPlex) and a petrolatum-based gel (Aquaphor) for preventing the development of dermatitis. Each patient was randomly assigned to use hyaluronic acid gel on the medial half or the lateral half of the irradiated breast and to use the control gel on the other half. Dermatitis was graded weekly according to the Common Terminology Criteria v3.0 by the treating physician, who was blinded as to which gel was used on which area of the breast. The primary endpoint was development of 鈮rade 2 dermatitis.
Results
The study closed early on the basis of a recommendation from the Data and Safety Monitoring Board after 74 of the planned 92 patients were enrolled. Breast skin treated with the hyaluronic acid gel developed a significantly higher rate of 鈮rade 2 dermatitis than did skin treated with petrolatum gel: 61.5%(40/65) vs. 47.7%(31/65) (p = 0.027). Only 1ne patient developed Grade 3 dermatitis using either gel. A higher proportion of patients had worse dermatitis in the breast segment treated with hyaluronic acid gel than in that treated with petrolatum gel at the end of radiotherapy (42%vs. 14%, p = 0.003).
Conclusion
We found no benefit from the use of a topical hyaluronic acid-based gel for reducing the development of 鈮rade 2 dermatitis after adjuvant radiotherapy for breast cancer. Additional studies are needed to determine the efficacy of hyaluronic acid-based gel in controlling radiation dermatitis symptoms after they develop