• 作者：Carlos Melero Moreno^a ; Antol&#237 ; n Ló ; pez-Viñ ; a^b ; ^{alopezv@separ.es} ; Mercedes Garc&#237 ; a-Salmones Mart&#237 ; n^c ; Carolina Cisneros Serrano^d ; Javier Jareñ ; o Esteban^e ; Maria Teresa Ramirez Prieto^f ; Grupo de Asma de Neumomadrid
• 关键词：Asma ; Hospitalizació ; n ; Hiperventilació ; n ; Sexo
• 刊名：Archivos de Bronconeumolog铆a
• 出版年：2012
• 期刊代码：pca65_03002896
• 类别：med
• 出版时间：July, 2012
• 卷：48
• 期：7
• 页码：234-239
• 文件大小：388 K

Introduction

The reason why there is a higher hospitalization rate due to asthma exacerbations amongst women is unclear. The objective of this study is to explore the possible causes that may explain this fact.

Methods

A multi-center, prospective study including asthma patients hospitalized in the pulmonary medicine departments during a two-year period.

By means of a questionnaire, the following data were collected: demographic characteristics and treatment compliance, anxiety-depression, hyperventilation and asthma control, both prior to and during the hospitalization.

Results

183 patients were included, 115 (62.84%) of whom were women. The women were older (52.4 卤 18.3/43.4 卤 18.7; P = .02), were more frequently prescribed inhaled corticosteroids (63.2%/47.1%; P = .03) and had a higher rate of hyperventilation syndrome (57.3/35.9; P = .02) and a longer mean hospital stay (7.3 卤 3.4/5.9 卤 3.6; P = .02). The percentage of smokers among the women was lower (21.2%/38.8%; p = 0.01) and the FEV₁ was lower at admittance (58.2%卤15.9/67.5% 卤 17.4; P = .03).

In the 40 to 60-year-old age range, an association was demonstrated between being female and the 芦previous hospitalizations禄 variable (OR, 16.1; 95%CI, 1.6-156.7); sex and obesity were also independently associated (OR, 4.8; 95%CI, 1.06-22).

Conclusions

In this cohort, the rate of hospitalization for asthma was higher in women than in men. Being a woman between the ages of 40 and 60 is associated with previous hospitalizations and is a risk factor for asthma-related hospitalization. This situation could partially be explained by the hormonal changes during menopause, where polyposis and obesity are independent risk factors.