Deficiencies of physiologic calcification inhibitors and low-grade inflammation in arterial calcification: lessons for cartilage calcification

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• 作者：Rutsch ; Frank ; Terkeltaub ; Robert
• 刊名：Joint Bone Spine
• 出版年：2005
• 期刊代码：138_1297319x
• 类别：med
• 出版时间：March, 2005
• 卷：72
• 期：2
• 页码：110-118
• 文件大小：347 K

摘要

Apart from clinical parallels, similarities in the pathogenesis of arterial and articular cartilage calcification have come to light in recent years. These include the roles of aging, of chronic low-grade inflammation and of genetic and acquired dysregulation of inorganic pyrophosphate (PP_i) metabolism. This review focuses on recent developments in understanding the pathogenesis of artery calcification pertinent to interpretation of the mechanistic basis for articular cartilage calcification in aging and osteoarthritis.