Ineffective erythropoiesis in β-thalassemia major is due to apoptosis at the polychromatophilic normoblast stage
- 作者：Mathias ; Liesl A. ; Fisher ; Timothy C. ; Zeng ; Licheng ; Meiselman ; Herbert J. ; Weinberg ; Kenneth I. ; et. al.
- 关键词：Progenitors ; Red blood cells ; Glycophorin A ; Terminal d-UTP nicked end labeling ; Erythroid liquid-culture
- 刊名：Experimental Hematology
- 出版年：2000
- 期刊代码：100_0301472x
- 类别：med
- 出版时间：December, 2000
- 卷：28
- 期：1
- 页码：1343-1353
- 文件大小：664 K
摘要
β-Thalassemia major is characterized by ineffective erythropoiesis, although it is difficult to define the dynamics of this process from the static information revealed by analysis of bone marrow (BM) aspirates. We aimed to study the kinetics of sequential erythroid differentiation in β-thalassemia major.