Indium-111 monoclonal antimyosin cardiac scintigraphy in suspected acute myocarditis: evolution and diagnostic impact
- 作者：Margari ; Zafiria J. ; Anastasiou-Nana ; Maria I. ; Terrovitis ; John ; Toumanidis ; Savas ; Agapitos ; Emmanuel V. ; et. al.
- 关键词：Antimyosin scintigraphy ; Cardiomyopathy ; Myocarditis ; AM ; acute myocarditis ; H/L ; heart/lung ; IDC ; idiopathic dilated cardiomyopathy ; LVEDd ; left ventricular end diastolic diameter ; LVEF ; LV ejection fraction ; LVESd ; left ventricular end systolic diameter
- 刊名：International Journal of Cardiology
- 出版年：2003
- 期刊代码：128_01675273
- 类别：med
- 出版时间：August, 2003
- 卷：90
- 期：2-3
- 页码：239-245
- 文件大小：501 K
摘要
Background: This study examined the evolution of the heart to lung (H/L) ratio of monoclonal antimyosin antibody (MAA) uptake in patients with suspected acute myocarditis (AM) and its time-dependent diagnostic value in conjunction with echocardiographic findings. Methods: The study included 20 patients with a short history (<4 months) of heart failure symptoms and normal coronary arteries. All patients underwent cardiac antimyosin scintigraphy, echocardiography, right-heart catheterization and endomyocardial biopsy. Patients who survived beyond 1 year were reevaluated with a cardiac antimyosin scintigraphy and an echocardiographic study. Results: Endomyocardial biopsy in 8/20 patients revealed findings compatible with the diagnosis of idiopathic dilated cardiomyopathy (group I) and in the remaining 12/20 was diagnostic of AM (group II). At baseline evaluation of the antimyosin H/L ratio uptake was similar in groups I and II, at 1.95±0.19 and 2.16±0.51, respectively (P